DRx Pharma Academy
Notes
Pharmacokinetics — Member Quick Notes
Pharmacology · 5 min read · Updated 02 Sept 2026
Core formulas
- Vd = Dose / C0.
- Clearance = Vd x Ke.
- t1/2 = 0.693 / Ke.
- Steady state reached in about 4-5 half lives.
First pass
- High first pass drugs: propranolol, morphine, lignocaine, nitroglycerin.
- Sublingual and rectal routes partially bypass first pass metabolism.