Notes
Tablet Technology & Quality Control
Pharmaceutics · 5 min read · Updated 23 Aug 2026
Granulation
- Wet granulation: mixing, wet massing, screening, drying, sizing, lubrication, compression.
- Dry granulation (slugging / roller compaction) for moisture and heat sensitive drugs.
- Direct compression uses free-flowing diluents like microcrystalline cellulose, spray-dried lactose.
Quality control tests
- Weight variation, hardness (4-10 kg/cm2), friability (< 1% w/w), disintegration, dissolution, content uniformity.
- Disintegration: uncoated 15 min, film coated 30 min, sugar coated 60 min, enteric coated 2 h acid + 1 h buffer.
Tablet defects
- Capping and lamination — entrapped air, over-dried granules.
- Sticking and picking — excess moisture, insufficient lubricant.
- Mottling — uneven dye distribution.